Seven million people's cancer could be prevented each year, according to the first global analysis. A report by World Health Organization (WHO) scientists estimates 37% of cancers are caused by infections, lifestyle choices and environmental pollutants that could be avoided. This includes cervical cancers caused by human papilloma virus (HPV) infections which vaccination can help prevent, as well as a host of tumours caused by tobacco smoke from cigarettes. The researchers said their report showed there is a powerful opportunity to transform the lives of millions of people. Some cancers are inevitable - either because of damage we unavoidably build up in our DNA as we age or because we inherit genes that put us at greater risk of the disease.

Cervical cancer is among the most commonly occurring cancer among women and claims a huge number of lives in low and middle-income countries despite being relatively easy to treat. Several studies have shown that public screening programs can bring down cervical cancer incidence and mortality rates significantly. While several screening tests are available, visual inspection with acetic acid (VIA) presents itself as the most viable option for low-resource settings due to the affordability and simplicity of performing the test. VIA requires a trained medical professional to interpret the test and is subjective in nature. Automating VIA using AI eliminates subjectivity and would allow shifting of the task to less trained health workers. Task shifting with AI would help further expedite screening programs in low-resource settings. In our work, we propose a lightweight deep learning algorithm that includes EfficientDet-Lite3 as the Region of Interest (ROI) detector and a MobileNet- V2 based model for classification. These models would be deployed on an android-based device that can operate remotely and provide almost instant results without the requirement of highly-trained medical professionals, labs, sophisticated infrastructure, or internet connectivity. The classification model gives an accuracy of 92.31%, a sensitivity of 98.24%, and a specificity of 88.37% on the test dataset and presents itself as a promising automated low-resource screening approach.

According to the data, the percent of women who underwent screening for cervical cancer, breast and oral cancer in Telangana in the year 2020 was 3.3 percent, 0.3 percent and 2.3 percent respectively. Although early detection is the only way to reduce morbidity and mortality, people have very low awareness about cervical and breast cancer signs and symptoms and screening practices. We developed an ML classification model to predict if a person is susceptible to breast or cervical cancer based on demographic factors. We devised a system to provide suggestions for the nearest hospital or Cancer treatment centres based on the users location or address. In addition to this, we can integrate the health card to maintain medical records of all individuals and conduct awareness drives and campaigns. For ML classification models, we used decision tree classification and support vector classification algorithms for cervical cancer susceptibility and breast cancer susceptibility respectively. Thus, by devising this solution we come one step closer to our goal which is spreading cancer awareness, thereby, decreasing the cancer mortality and increasing cancer literacy among the people of Telangana.

In order to support the creation of reliable machine learning models for anomaly detection, this project focuses on preprocessing, enhancing, and organizing a medical imaging dataset. There are two classifications in the dataset: normal and abnormal, along with extra noise fluctuations. In order to improve the photographs' quality, undesirable artifacts, including visible medical equipment at the edges, were eliminated using central cropping. Adjusting the brightness and contrast was one of the additional preprocessing processes. Normalization was then performed to normalize the data. To make classification jobs easier, the dataset was methodically handled by combining several image subsets into two primary categories: normal and pathological. To provide a strong training set that adapts well to real-world situations, sophisticated picture preprocessing techniques were used, such as contrast enhancement and real-time augmentation (including rotations, zooms, and brightness modifications). To guarantee efficient model evaluation, the data was subsequently divided into training and testing subsets. In order to create precise and effective machine learning models for medical anomaly detection, high-quality input data is ensured via this thorough approach. Because of the project pipeline's flexible and scalable design, it can be easily integrated with bigger clinical decision-support systems.

Cervical cancer remains the fourth most common malignancy amongst women worldwide.1 Concurrent chemoradiotherapy (CRT) serves as the mainstay definitive treatment regimen for locally advanced cervical cancers and includes external beam radiation followed by brachytherapy.2 Integral to radiotherapy treatment planning is the routine contouring of both the target tumor at the level of the cervix, associated gynecologic anatomy and the adjacent organs at risk (OARs). However, manual contouring of these structures is both time and labor intensive and associated with known interobserver variability that can impact treatment outcomes. While multiple tools have been developed to automatically segment OARs and the high-risk clinical tumor volume (HR-CTV) using computed tomography (CT) images,3,4,5,6 the development of deep learning-based tumor segmentation tools using routine T2-weighted (T2w) magnetic resonance imaging (MRI) addresses an unmet clinical need to improve the routine contouring of both anatomical structures and cervical cancers, thereby increasing quality and consistency of radiotherapy planning. This work applied a novel deep-learning model (PocketNet) to segment the cervix, vagina, uterus, and tumor(s) on T2w MRI. The performance of the PocketNet architecture was evaluated, when trained on data via 5-fold cross validation. PocketNet achieved a mean Dice-Sorensen similarity coefficient (DSC) exceeding 70% for tumor segmentation and 80% for organ segmentation. These results suggest that PocketNet is robust to variations in contrast protocols, providing reliable segmentation of the ROIs.

Cervical cancer affects millions of women worldwide and has a significantly higher survival rate when diagnosed early. Pap smears and cervical biopsies are vital screening tools for detecting such cancer. However, the success of these screening processes depends on the skills of cytologists. A recent trend in diagnostic cytology is to apply machine-learning-based models to classify cancer using cell images. These automated models have been shown to perform just as well as, or even better than, expert cytologists. Some notable methods for classifying cervix cancers include ResNet50, VGG16, MobileNetV2, and InceptionV3, based on deep convolutional neural networks (CNN). However, these methods are computationally expensive. We present CerviXpert, a multi-structural Convolutional Neural Network, to identify cervix cancer. We perform extensive experiments on a publicly available dataset, SiPaKMeD, to show the efficacy of our method. CerviXpert presents a promising solution for efficient cervical cancer screening and diagnosis by striking a balance between accuracy and practical feasibility.

This paper proposes an efficient system for classifying cervical cancer cells using pre-trained convolutional neural networks (CNNs). We first fine-tune five pre-trained CNNs and minimize the overall cost of misclassification by prioritizing accuracy for certain classes that have higher associated costs or importance. To further enhance the performance of the models, supervised contrastive learning is included to make the models more adept at capturing important features and patterns. Extensive experimentation are conducted to evaluate the proposed system on the SIPaKMeD dataset. The experimental results demonstrate the effectiveness of the developed system, achieving an accuracy of 97.29%. To make our system more trustworthy, we have employed several explainable AI techniques to interpret how the models reached a specific decision. The implementation of the system can be found at - https://github.com/isha-67/CervicalCancerStudy.

Treatment for high-grade precancerous cervical lesions and early-stage cancers, mainly affecting women of reproductive age, often involves fertility-sparing treatment methods. Commonly used local treatments for cervical precancers have shown the risk of leaving a positive cancer margin and engendering subsequent complications according to the precision and depth of excision. An intra-operative device that allows the careful excision of the disease while conserving healthy cervical tissue would potentially enhance such treatment. In this study, we developed a polymer-based robotic fiber measuring 150 mm in length and 1.7 mm in diameter, fabricated using a highly scalable fiber drawing technique. This robotic fiber utilizes a hybrid actuation mechanism, combining electrothermal and tendon-driven actuation mechanisms, thus enabling a maximum motion range of 46 mm from its origin with a sub-100 {\mu}m motion precision. We also developed control algorithms for the actuation methods of this robotic fiber, including predefined path control and telemanipulation, enabling coarse positioning of the fiber tip to the target area followed by a precise scan. The combination of a surgical laser fiber with the robotic fiber allows for high-precision surgical ablation. Additionally, we conducted experiments using a cervical phantom that demonstrated the robotic fiber's ability to access and perform high-precision scans, highlighting its potential for cervical disease treatments and improvement of oncological outcomes.

Query expansion has been proved to be effective in improving recall and precision of first-stage retrievers, and yet its influence on a complicated, state-of-the-art cross-encoder ranker remains under-explored. We first show that directly applying the expansion techniques in the current literature to state-of-the-art neural rankers can result in deteriorated zero-shot performance. To this end, we propose GFF, a pipeline that includes a large language model and a neural ranker, to Generate, Filter, and Fuse query expansions more effectively in order to improve the zero-shot ranking metrics such as nDCG@10. Specifically, GFF first calls an instruction-following language model to generate query-related keywords through a reasoning chain. Leveraging self-consistency and reciprocal rank weighting, GFF further filters and combines the ranking results of each expanded query dynamically. By utilizing this pipeline, we show that GFF can improve the zero-shot nDCG@10 on BEIR and TREC DL 2019/2020. We also analyze different modelling choices in the GFF pipeline and shed light on the future directions in query expansion for zero-shot neural rankers.

We introduce a new task called *entity-centric question generation* (ECQG), motivated by real-world applications such as topic-specific learning, assisted reading, and fact-checking. The task aims to generate questions from an entity perspective. To solve ECQG, we propose a coherent PLM-based framework GenCONE with two novel modules: content focusing and question verification. The content focusing module first identifies a focus as "what to ask" to form draft questions, and the question verification module refines the questions afterwards by verifying the answerability. We also construct a large-scale open-domain dataset from SQuAD to support this task. Our extensive experiments demonstrate that GenCONE significantly and consistently outperforms various baselines, and two modules are effective and complementary in generating high-quality questions.